Catalytic asymmetric conjugate addition of Grignard reagents to chromones.
نویسندگان
چکیده
A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 53 شماره
صفحات -
تاریخ انتشار 2013